学位：博士学位
学历：博士研究生毕业
职称：教授
单位：生命科学学院
曹博——
博士，讲师，青年教授。主要研究方向为分子遗传学领域，包括利用基因组学、酶学、分析化学、分子生物学等多种研究手段，发现DNA和RNA等生物大分子上的新型表观遗传修饰和损伤修饰，并揭示不同的修饰类型在细胞发育、癌症发生、抗药性等方面的调控功能及作用机理。
2014年毕业于上海交通大学生物学系并获博士学位。并在美国麻省理工学院、新加坡MIT-SMART联合研究所进行肿瘤细胞形成的分子机理、生物标志物发现、基因治疗新靶标开发等。
迄今为止，作为主要完成人参与科技部“973”计划、中国自然科学基金、美国国立卫生研究院重大研究计划（NIH-RO1）、美国自然科学基金等共6项课题，累计科研经费1300余万元。共发表SCI科研论文13篇,包括(Nature Biotechnology, Nature Chemical Biology，Nature Communications，PNAS, Nuleic Acids Research, Molecular Microbiology，Scientific Report, etc); 开发中国专利四项、美国专利两项、国际PCT专利两项。
Bo Cao#; Chao Chen#; Michael S. DeMott#; Qiuxiang Cheng; Tyson A. Clark; Xiaoqing Zheng; Vincent Butty; Stuart S. Levine; Matthew Boitano; Jonas Korlach; Delin You*; Lianrong Wang*; Shi Chen*; Peter Dedon, Genomic mapping of phosphorothioates reveals partial modification of short consensus sequences., Nature Communications, 2014.6.5, 3591(2014)
Bo Cao; Qiuxiang Cheng; Chen Gu; Fen Yao; Michael S. DeMott; Xiaoqing Zheng; Zixin Deng; Peter Dedon*; Delin You*, Pathological phenotypes and in vivo DNA cleavage by unrestrained activity of a phosphorothioate-based restriction system in Salmonella., Molecular Microbiology, 2014.7.10, 93(4):776~785
Bo Cao; Xiaoqing Zheng; Qiuxiang Cheng; Fen Yao; Tao Zheng; Rumash Babu; Huchen Zhou; Peter Dedon; Delin You*, In vitro analysis of phosphorothioate modification of DNA reveals substrate recognition by a multiprotein complex., Sci Rep., 2015.7.27, 5(12531)
Qiuxiang Cheng#; Bo Cao#; Fen Yao; Jinli Li; Zixin Deng; Delin You*，Regulation of DNA phosphorothioate modifications by the transcriptional regulator DptB in Salmonella., Molecular Microbiology, 2015.6.19, 97(6): 1186~1194
Stefanie Kellner; Michael S DeMott; Ching Pin Cheng; Brandon S Russell; Bo Cao; Delin You; Peter C Dedon*, Oxidation of phosphorothioate DNA modifications leads to lethal genomic instability., Nature Chemical Biology, 2017.6.12, 2017(13): 888~894
Bo Cao#; Fen Yao#; Xiaoqing Zheng; Dongbing Cui; Yucheng Shao; Changxiong Zhu; Delin You*, Genome mining of the biosynthetic gene cluster of the polyene macrolide antibiotic tetramycin and characterization of a P450 monooxygenase involved in the hydroxylation of the tetramycin B polyol segment., Chembiochem, 2012.10.15, 2012(13): 2234~2242
Xiaoqing Zheng; Qiuxiang Cheng; Fen Yao; Xiaozheng Wang; Lingxin Kong; Bo Cao; Min Xu; Shuangjun Lin; Yit-Heng Chooi; Delin You*, Biosynthesis of the pyrrolidine protein synthesis inhibitor anisomycin involves novel gene ensemble and cryptic biosynthetic steps., Proc Natl Acad Sci U S A., 2017.4.18, 114(16): 4135~4140
Lingxin Kong; Weike Zhang; Yit Heng Chooi; Lu Wang; Bo Cao; Zixin DENG; Yiwen Chu; Delin You*, A Multifunctional Monooxygenase XanO4 Catalyzes Xanthone Formation in Xantholipin Biosynthesis via a Cryptic Demethoxylation., Cell Chem Biol., 2016.4.21, 23(4)
Tao Zheng; Pan Jiang; Bo Cao; Qiuxiang Cheng; Linxin Kong; Xiaoqing Zheng; Qinghai Hu; Delin You*，DndEi Exhibits Helicase Activity Essential for DNA Phosphorothioate Modification and ATPase Activity Strongly Stimulated by DNA Substrate with a GAAC/GTTC Motif., J Biol Chem., 2016.1.15, 291(3): 1492~1500